Elements of Transcription Factor Network Design for T-Lineage Specification
نویسندگان
چکیده
منابع مشابه
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNgamma. T-bet expression correlates with IFNgamma expression in Th1 and NK cells. Ectopic expression of T-bet both transactivates the IF...
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Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique 'zinc knuckle', which medi...
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Gillian May,1,2,10 Shamit Soneji,1,2,7,10 Alex J. Tipping,1,2,8 Jose Teles,1,3 Simon J. McGowan,4 Mengchu Wu,5 Yanping Guo,1,2 Cristina Fugazza,1,2 John Brown,1,2 Göran Karlsson,1,7 Cristina Pina,1,2,9 Victor Olariu,3 Stephen Taylor,4 Daniel G. Tenen,5,6 Carsten Peterson,3 and Tariq Enver1,2,* 1Stem Cell Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK 2Molecular Haem...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2002
ISSN: 0012-1606
DOI: 10.1006/dbio.2002.0667